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Tetracycline-stained teeth. Used to combat bacterial infections, acne and “traveler’s diarrhea,” tetracycline was widely used on children from the 1950s until about 1980. Tetracycline teeth stains develop on permanent teeth while they are still forming under the gum line. During development, the drug becomes calcified in the tooth, generating tetracycline tooth stains. Children are susceptible to tetracycline tooth stains from the time they are in utero until the age of 8.